Contract Research
Models
William Harvey Research Ltd (WHRL) is a preclinical contract research organisation who has been working with Biotech and Pharmaceutical sectors since 1990. A primary aim of WHRL is to co-ordinate contract research as an Efficacy, Verification and Interpretation Service (EVIS).
With a catalogue of more than 120 in vivo and in vitro models available alongside flexible experimental design and expert advice from our Lead Scientists at the William Harvey Research Institute, we aim to deliver excellent standards of research.
To view our models please select a research area from the list on the left. An outline of the main areas of service we provide is also given below.
Models of Inflammation
The development of new anti-inflammatory therapeutics usually entails the assessment of drug efficacy in disease models. Determining the potential effects on multiple parameters of the inflammatory response offers clear benefits at early stages of discovery programmes.
We offer a broad range of validated models, as well as more sophisticated approaches to assess the anti-inflammatory potential of new candidates. Please select Inflammation from the list on the left in order to view a full list of the services available within this area.
Models of Cardiovascular Disease
Early stage development of new cardiovascular therapeutics frequently necessitates the evaluation of drug efficacy in disease models. Establishing possible effects on multiple parameters of the cardiac and vascular responses has a catalytic impact on discovery programmes.
Our models span the analysis of tissue injury in the heart, the kidneys and the liver. Please select Cardiovascular from the list on the left in order to view these available services.
Cell Based Assays
We provide several meaningful and sophisticated analyses using primary and immortalised cells to kick-start drug discovery programmes downstream of compound identification. It is imperative to ascertain whether new receptor ligands display agnostic or antagonistic activities; similarly, identification of cell targets can direct further development stages, influencing downstream pre-clinical studies.
Our assays of cell activation span from signalling responses to cell specific readouts. For a list of available assays, please select Cellular from the list on the left.
Proof-of-concept Disease Models
We have extensive experience of helping clients select models of cardiovascular and inflammatory pathologies that deliver robust, proof-of-concept results. This has an impact on the definition of the human condition(s) to target with our client’s product.
Modelling human pathologies to furnish proof-of-concept results is available in arthritis, multiple sclerosis, colitis, chronic heart failure as well as metabolic syndrome and obesity. A comprehensive list of the models we offer is available in our online catalogue.
Please select a research area of interest from the list on the left or alternatively, contact us directly to speak with one of our scientists.
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