Books
Highlights

William Harvey Press
Books - Clinical Significance and Potential of Selective COX-2 Inhibitors

SUMMARY
This volume reviews the current knowledge of the role of cyclooxygenase-2 in inflamed
joints, cancers, Alzheimer's disease and parturition and presents data to demonstrate how
the gastrointestinal and renal toxicity of non-steroid anti-inflammatory drugs can be avoided
by the use of preferential inhibitors of cyclooxygenase-2.

(Combined proceedings of the William Harvey Research Conferences held in
Phuket, Thailand, 18-19th September, 1997 and in Boston, USA, 23-24th April, 1998)

CONTENTS

• List of contributors
• Preface
• Overview: The mechanism of action of anti-inflammatory drugs
  JR Vane and RM Botting
• Tests for cyclooxygenase-1 and -2 inhibition
  M. Pairet and J. van Ryn
• Differential target tissue presentation and cyclooxygenase-2 and -1 inhibition by non-steroidal anti-inflammatory drugs
  H. Fenner
• Cyclooxygenase-1 and -2 in synovial tissues of arthritis patients
  L.J. Crofford
• Cyclooxygenase-2 and bone resorption
  C.C. Philbeam
• The clinical epidemiology of non-steroidal anti-inflammatory drug gastropathy
  J.F. Fries, G. Singh and D.R. Ramey
• Experimental basis for non-steroidal anti-inflammatory drug-induced gut injury
  B.J.R. Whittle
• Gastrointestinal effects of non-steroidal anti-inflammatory drugs
  CJ Hawkey
• Management of non-steroidal anti-inflammatory drug-related gastrointestinal mucosal injury
  C.-C. Tseng and M.M. Wolfe
• Avoidance of renal side effects of non-steroidal anti-inflammatory drugs: value of selective cyclooxygenase-2 inhibition
  D.O. Stichtenoth and J.C. Frolich
• Cyclooxygenase is expressed functionally in the renal thick ascending limb via angiotensin II stimulation of tumour necrosis factor-α
  N.R. Ferreri, J.C. McGiff and C.P. Vio
• Expression of cyclooxygenase-2 in human gastric carcinoma
  A. Ristimaki
• Suppression of intestinal polyposis by inhibition of cyclooxygenase-2 in a mouse model for familial adenomatous polyposis
  M.M.Taketo
• Meloxicam inhibits the growth of colorectal cancer cells
  A.P. Goldman, C.S. Williams, L.W. Lamps, V.P. Williams, M. Pairet, J.D. Morrow and R.N. DuBois
• Adverse effects of non-steroidal anti-inflammatory drugs on the gastrointestinal tract and kidney: relationship to cyclooxygenase-2 selectivity
  P. McGettigan, D. Henry and J. Page
• Overview of MELISSA and SELECT clinical trials of meloxicam
  A. Kahan
• The role of cyclooxygenase-2 in reproduction
  P. Bennett, R. Sawdy and D. Slater
• Cyclooxygenase-2 in Alzheimer's disease
  M.K. O-Banion