Books
Highlights

William Harvey Press
Books - Selective COX2 inhibitors Pharmacology, clinical effects and therapeutic potential

SUMMARY
This volume describes the present knowledge of the structures of the cycloooxygenase isoforms and the experimental and clinical effects of selective inhibitors of cyclooxygenase-2. The pathophysiological significance of the cyclooxygenase enzymes in tumorigenesis, programmed cell death, vascular disease and asthma is also covered.

(Proceedings of the William Harvey Research Conference held in Cannes, France,
20th-21st March 1997)

CONTENTS

• List of contributors
• Preface
• Mechanism of action of anti-inflammatory drugs: an overview
  JR Vane and RM Botting
• The structure of human COX-2 and selective inhibitors
  MF Browner
• Differential inhibition of COX-1 and COX-2 by NSAIDs: a summary of results obtained using various test systems
  M Pairet, J van Ryn, A Mauz, H Schierok, W Diederen, D Türck, G Engelhart
• COX-2 in brain and retina: role in neuronal survival
  NG Bazan, VL Marcheselli, PK Mukherjee, WJ Lukiw, WC Gordon, D Zhang
• COX-2 and apoptosis: NSAIDs as effectors of programmed cell death
  DL Simmons, ML Madsen, PM Robertson
• Inhibition of intestinal tumorigenesis via selective inhibition of COX-2
  RN Dubois, H Sheng, J Shao, C Williams, RD Beauchamp
• Cyclooxygenase enzyme in human vascular disease
  C Patrono, F Cipollone, G Renda, P Patrignani
• Gastrointestinal effect of NSAIDs
  CJ Hawkey
• Renal side effects of NSAIDs: role of COX-1 and COX-2
  JC Frölich, DO Stichtenoth
• Aspirin-induced asthma and cyclooxygenases
  RJ Grylewski
• New classification for aspirin-like drugs
  H Fenner
• New highly selective COX-2 inhibitors
  AW Ford-Hutchinson
• Specific COX-2 inhibitors: from bench to bedside
  P Isakson, B Zweifel, J Masferrer, C Koboldt, K Seibert, R Hubbard, S Geis, P Needleman
• Meloxicam: selective COX-2 inhibition in clinical practice
  DE Furst