Overview-mechanisms of action of anti-inflammatory drugs
John Vane and Regina Botting
The three-dimensional structure of cyclooxygenases
R. Michael Garavito
The dilemma of two cyclooxygenases: Identifying the
roles of COX-1 and COX-2 in inflammation and apoptosis
Daniel Simmons, Xiaojun Lu, William Bradshaw and Weilin Xie
Inducible enzymes with special reference to COX-2 in
the inflammatory response
Derek Willoughby, Annette Tomlinson, Derek Gilroy and Dean Willis
NSAID mechanism of action: the role of intracellular
pharmacokinetics
Leo Herbette, Michelle Vecchiarelli and Gunther-Trummlitz
Differential inhibition of COX-1 and COX-2 in vitro
and pharmacological profile in vivo of NSAIDs
Michel Pairet and Gunther Engelhardt
COX-2 expression and inhibition in human monocytes
Carlo Patrono, Paola Patrignani, Maria Panara, Francesco Cipollone,
na Santini, Maria Sciulli, Maria Rotondo, Roberto Padovano and
Maria Giamberardino
Expression and regulation of COX-2 in synovial tissues
of arthritic patients
Leslie Crofford
An inhibitor of injury-induced COX-2 transcriptional
activation elicits neuroprotection in a brain damage model
Niicolas Bazan and Geoffrey Allan
COX-2 expression in labour
Phillip Bennett and Donnal Slater
Re-evaluation of gut toxicity of NSAIDs
D Nicholas Bateman
NSAID: can renal side effects be avoided?
Jurgen Frolich and Dirk Stichtenoth
Pharmacology, safety data and therapeutics of COX-2
inhibitors
Paul Emery
Index
March 1996 230 pages ISBN 0-7923-8897-6
Hardbound GBP 58.50/NLG 130/USD 91
