Books
Highlights

William Harvey Press
Books - New Targets in Inflammation - Inhibitors of Cox-2 or Adhesion Molecules

SUMMARY
The general pathophysiological significance of the isoforms of cycloooxygenase and the likely value of selective COX-2 inhibitors in the treatment of rheumatoid conditions is reviewed. The volume also covers the possible use of antibodies against cytokines and cell adhesion receptors in the treatment of inflammatory conditions.

(Proceedings of the William Harvey Research Conference held in New Orleans,
15-16th April 1996)

CONTENTS

• List of contributors
• Preface
• The history of anti-inflammatory drugs and their mechanism of action
  J.R.Vane and R.M. Botting
• Structure of prostaglandin H2 synthase-1 (COX-1) and its NSAID binding sites
  P.J. Loll
• Differential inhibition of cyclooxygenases 1 and 2 by NSAIDs
  M. Pairet, L. Churchill and G. Engelhardt
• Blockade of inflammatory hyperalgesia and cyclooxygenase-2
  S.H. Ferreira
• Brain COX-2 in experimental models of epilepsy and stroke: signalling pathways leading to enhanced expression
  N.G Bazan, V.M. Marcheselli, G. Allan, K. Van Meter and J.P. Moises
• New highly selective cyclooxygenase-2 inhibitors
  A.W. Ford-Hutchinson
• Characteristics of cyclooxygenase-1 and cyclooxygenase-2-deficient mice
  S.G. Morham and R. Langenbach
• X-ray crystal structure of human cyclooxygenase-2
  M. Browner
• Risk of gastrointestinal side effects caused by non-steroid anti-inflammatory
  drugs (NSAIDs)
  H. Jick
• Expression and regulation of cyclooxygenase-2 in synovial tissues of arthritic patients
  L.J. Crofford
• Differential target tissue presentation and COX-1/COX-2 inhibition by non-steroid anti-inflammatory drugs: a rationale for a new classification
  H. Fenner
• Clinical experience with meloxicam, a selective COX-2 inhibitor
  W.Bolten
• Enzymatic regulation of the prostaglandin response in a human model
  of inflammation
  B.F. Adam and G.A. Fitzgerald
• Cyclooxygenase-2 and intestinal cancer
  R.N. DuBois, A. Radhika, J. Shao, M. Tsujii, H. Sheng, O. Kobyashi, R.D. Beauchamp and C.S. Williams
• Cytokines and adhesion molecules in the lung inflammatory response
  P.A. Ward
• Adhesion molecules as targets for therapy in rheumatoid arthritis
  P.E. Lipsky, A.F. Kavanaugh, H. Schulze-Koops and L.S . Davis

  November 1996 160 pages
  ISBN 0-7923-8714-7
  
  Hardbound
  GBP 49/NLG 115/USD 74